HCID 86688408, compound → HCID 86688407, compound

HRID 1477757Notes

Reaction equation

HRID 1477757 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13]C(=O)C2C=CC=CC=2)=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]>[OH-].[Na+]>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH2:13])=[S:12])[N:7]([CH2:22][CH3:23])[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 86688408HCID 86688408, compound

Product 1

HCID 86688407HCID 86688407, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of compound 24 (5 g, 15.1 mmol) in 30 mL of 5% NaOH aqueous solution was stirred in an oil bath of 90° C. for 8 hrs and cooled down to room temperature. Ice was added while stirring to the reaction mixture. The resulting suspension was filtered, and the cake was washed with cold water (10 mL×3) and further dried in vacuo to afford the desired product 8 as an off-white powder.

Workup

  1. temperaturecooled down to room temperature
  2. additionIce was added
  3. stirringwhile stirring to the reaction mixture
  4. filtrationThe resulting suspension was filtered
  5. washthe cake was washed with cold water (10 mL×3)
  6. customfurther dried in vacuo

Sources & evidence

ORD record
ord-5d1cc4a3486b489aabbd729ff583c6fd
Source dataset
uspto-grants-2016_08
Patent number
US09403815B2

Reaction notes

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