Acetic Anhydride → N-(6-bromo-2-methoxypyridin-3-yl)formamide

Participants

Reaction Steps

Acetic anhydride (203 mL) was added dropwise to formic acid (204 mL) under ice-cooling, and the mixture was stirred at the same temperature for 25 min. 6-bromo-2-methoxypyridine-3-amine power (CAS#89466-18-2, 146 g) was put into the reaction mixture over 10 minutes, and the reaction solution was stirred at the same temperature for 30 minutes. The water bath was removed. tert-Butyl methyl ether (300 mL) and n-heptane (500 mL) were sequentially added dropwise to the reaction solution, and then the reaction solution was stirred for 30 minutes.

Provenance & Evidence