HCID 86688406, compound → HCID 86688405, compound

HRID 1477764Notes

Reaction equation

HRID 1477764 reaction equation
[CH3:1][N:2]1[C:10]([NH:11][C:12]([NH:14]C(=O)C2C=CC=CC=2)=[S:13])=[C:9]2[C:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)=[N:3]1>[OH-].[Na+]>[CH3:1][N:2]1[C:10]([NH:11][C:12]([NH2:14])=[S:13])=[C:9]2[C:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)=[N:3]1

Participants

3

Reactant 1

HCID 86688406HCID 86688406, compound

Product 1

HCID 86688405HCID 86688405, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of compound 125 (3.1 g, 9.5 mmol) in 30 mL of 5% NaOH aqueous solution was stirred in an oil bath of 90° C. for 8 hrs and cooled down to room temperature. Ice was added while stirring to the reaction mixture. The resulting suspension was filtered, and the cake was washed with cold water (10 mL×3) and further dried in vacuo to afford the desired product 113 as an off-white powder.

Workup

  1. temperaturecooled down to room temperature
  2. additionIce was added
  3. stirringwhile stirring to the reaction mixture
  4. filtrationThe resulting suspension was filtered
  5. washthe cake was washed with cold water (10 mL×3)
  6. customfurther dried in vacuo

Sources & evidence

ORD record
ord-e482b2756f2e469ea40eee7561bca413
Source dataset
uspto-grants-2016_08
Patent number
US09403815B2

Reaction notes

Loading…