Azetidine → HCID 71525484, compound

HRID 1477769Notes

Reaction equation

HRID 1477769 reaction equation
[CH3:1][C:2]([NH:10][C:11]([C:13]1[CH:18]=[N:17][C:16](Br)=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=2)[N:14]=1)=[O:12])([C:4]1[N:8]=[C:7]([CH3:9])[O:6][N:5]=1)[CH3:3].[NH:27]1[CH2:30][CH2:29][CH2:28]1>>[CH3:1][C:2]([NH:10][C:11]([C:13]1[CH:18]=[N:17][C:16]([N:27]2[CH2:30][CH2:29][CH2:28]2)=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=2)[N:14]=1)=[O:12])([C:4]1[N:8]=[C:7]([CH3:9])[O:6][N:5]=1)[CH3:3]

Participants

3

Reactant 2

HCID 10422AzetidineHCID 86682317HCID 86682317, compound

Product 1

HCID 71525484HCID 71525484, compound

Procedure

The title compound was synthesized in analogy to Example 4, using 5-bromo-6-(3-chloro-phenyl)-pyrazine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide (Example 1e) and azetidine as starting materials, and isolated (29 mg, 41%) as light yellow oil; MS (EI): 413.2 (M+H).

Workup

  1. customisolated (29 mg, 41%) as light yellow oil

Sources & evidence

ORD record
ord-8f944dea115740ebb8f638249c45af8e
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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