3-Amino-3-methylbutan-1-ol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (3-hydroxy-1,1-dimethyl-propyl)-amide

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Reaction Steps

The title compound was synthesized in analogy to Example 8e, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and 3-amino-3-methyl-1-butanol (CAN 42514-50-1; 58.46 mg, 0.51 mmol) as starting materials, and isolated (15 mg, 10.9%) as off white solid; LC-MS (UV peak area, ESI) 100%, 320.4 (M+H).

Provenance & Evidence