HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Aminocyclobutyl)methanol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (1-hydroxymethyl-cyclobutyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Aminocyclobutyl)methanol | HCID 21624254 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid | HCID 86682331 | — |
| Product | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (1-hydroxymethyl-cyclobutyl)-amide | HCID 71525573 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 8e, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and 1-amino-cyclobutanemethanol (CAN 180205-34-9, 66.02 mg, 0.64 mmol) as starting materials, and isolated (50 mg, 36.86%) as off white solid; LC-MS (UV peak area, ESI) 97.56%, 318.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403808B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-9195a944b9034f6582a2a2b9707596f7 |
| Source note | uspto-grants-2016_08 |