(2S)-2-Amino-N,3,3-trimethylbutanamide → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Participants

Reaction Steps

The title compound was synthesized in analogy to Example 8e, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and (S)-2-amino-3,3,N-trimethyl-butyramide (CAN 89226-12-0, 106.7 mg, 0.64 mmol) as starting materials, and isolated (45 mg, 29.4%) as off white solid, LC-MS (UV peak area, ESI) 100%, 361.4 (M+H).

Provenance & Evidence