HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-3-Amino-4-cyclopropyl-2-methyl-butan-2-ol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-cyclopropylmethyl-2-hydroxy-2-methyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-3-Amino-4-cyclopropyl-2-methyl-butan-2-ol | HCID 86674766 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid | HCID 86682331 | — |
| Product | 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-cyclopropylmethyl-2-hydroxy-2-methyl-propyl)-amide | HCID 86682332 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.43 mmol) and (S)-3-amino-4-cyclopropyl-2-methyl-butan-2-ol (87.83 mg, 0.64 mmol) as starting materials, and isolated (20 mg, 13.03%) as off white solid, LC-MS (UV peak area, ESI) 98.68%, 360.8 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403808B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-1885f22bf271491bbfe5cd1cc259d3d4 |
| Source note | uspto-grants-2016_08 |