2-Amino-2-cyclopropylethanol → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyrazine-2-carboxylic acid (1-cyclopropyl-2-hydroxy-ethyl)-amide

Participants

Reaction Steps

The title compound was synthesized in analogy to Example 15, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyrazine-2-carboxylic acid (Example 8d, 100 mg, 0.35 mmol) and β-amino-cyclopropaneethanol (CAN 776315-67-4, 78.94 mg, 0.53 mmol) as starting materials, and isolated (20 mg, 14.91%) as light brown solid; LC-MS (UV peak area, ESI) 97.84%, 368.9 (M+H).

Provenance & Evidence