5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid → HCID 71525670, compound

HRID 1477788Notes

Reaction equation

HRID 1477788 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@@H:20]([CH2:25][CH:26]1[CH2:28][CH2:27]1)[C:21]([NH:23][CH3:24])=[O:22]>>[CH:26]1([CH2:25][C@H:20]([NH:19][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[C:21](=[O:22])[NH:23][CH3:24])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acidHCID 86682333HCID 86682333, compound

Product 1

HCID 71525670HCID 71525670, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and (S)-2-amino-3-cyclopropyl-N-methyl-propionamide hydrochloride (1:1) (Example 24b) as starting materials, and isolated (77 mg, 89%) as light yellow oil; LC-MS (UV peak area, ESI) 100%, 359.2081 (M+H).

Workup

  1. customisolated (77 mg, 89%) as light yellow oil

Sources & evidence

ORD record
ord-57484e24abf6476ab7214cc5f23ea272
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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