HCID 86678866, compound → HCID 71525761, compound

HRID 1477791Notes

Reaction equation

HRID 1477791 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@@H:20]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:21]([N:23]([CH3:25])[CH3:24])=[O:22]>>[CH3:25][N:23]([CH3:24])[C:21]([C@@H:20]([NH:19][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH2:26][CH:27]([CH3:28])[CH3:29])=[O:22]

Participants

3

Reactant 2

HCID 86678866HCID 86678866, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71525761HCID 71525761, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and (2S)-2-amino-N,N,4-trimethyl-pentanamide hydrochloride (1:1) (CAN 207595-81-1) as starting materials, and isolated (68 mg, 85%) as yellow solid; LC-MS (UV peak area, ESI) 100%, 375.2387 (M+H).

Workup

  1. customisolated (68 mg, 85%) as yellow solid

Sources & evidence

ORD record
ord-189f9366945441318416c3375e68e45d
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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