HCID 61310570, compound → HCID 78098473, compound

HRID 1477797Notes

Reaction equation

HRID 1477797 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH:18]1([CH:21]([C:23]2[N:27]=[C:26]([CH3:28])[O:25][N:24]=2)[NH2:22])[CH2:20][CH2:19]1>>[CH:18]1([CH:21]([NH:22][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])[C:23]2[N:27]=[C:26]([CH3:28])[O:25][N:24]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 61310570HCID 61310570, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 78098473HCID 78098473, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and α-cyclopropyl-5-methyl-1,2,4-oxadiazole-3-methanamine (CAN 1291557-80-6) as starting materials, and isolated (95 mg, 86%) as light yellow solid; LC-MS (UV peak area, ESI) 100%, 370.1876 (M+H).

Workup

  1. customisolated (95 mg, 86%) as light yellow solid

Sources & evidence

ORD record
ord-cc98a3ec40164b6888b3a250bb7258a5
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

Loading…