1240526-27-5 → HCID 71525944, compound

HRID 1477799Notes

Reaction equation

HRID 1477799 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[CH3:19][C:20]([CH3:28])([C:22]1[N:26]=[C:25]([CH3:27])[O:24][N:23]=1)[NH2:21]>>[CH3:19][C:20]([NH:21][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:22]1[N:26]=[C:25]([CH3:27])[O:24][N:23]=1)[CH3:28]

Participants

3

Reactant 2

HCID 470030731240526-27-5HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71525944HCID 71525944, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and α,α,5-trimethyl-1,2,4-oxadiazole-3-methanamine hydrochloride (CAN 1240526-27-5) as starting materials, and isolated (64 mg, 84%) as light yellow solid; LC-MS (UV peak area, ESI) 100%, 358.1869 (M+H).

Workup

  1. customisolated (64 mg, 84%) as light yellow solid

Sources & evidence

ORD record
ord-d851cd28496c4598b757b7c6f81116b5
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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