(S)-2-amino-2,3-dimethylbutan-1-ol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide

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Reaction Steps

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g; 100 mg, 0.42 mmol) and (2S)-2-amino-2,3-dimethyl-1-butanol (CAN 956102-64-0, 107.06 mg, 0.64 mmol) as starting materials, and isolated (25 mg, 16.04%) as off white sticky solid, LC-MS (UV peak area, ESI) 90.02%, 334.4 (M+H).

Provenance & Evidence