HCID 86674783, compound → HCID 71526128, compound

HRID 1477806Notes

Reaction equation

HRID 1477806 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([C:23]1[N:27]=[C:26]([NH2:28])[O:25][N:24]=1)([CH3:22])[CH3:21]>>[NH2:28][C:26]1[O:25][N:24]=[C:23]([C:20]([NH:19][C:15]([C:7]2[CH:6]=[N:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])([CH3:22])[CH3:21])[N:27]=1

Participants

3

Reactant 2

HCID 86674783HCID 86674783, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526128HCID 71526128, compound

Procedure

The title compound was synthesized in analogy to Example 6, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g) and 3-(1-amino-1-methyl-ethyl)-[1,2,4]oxadiazol-5-ylamine hydrochloride (1:1) (Example 57b) as starting materials, and isolated (57 mg, 75%) as off-white solid; LC-MS (UV peak area, ESI) 100%, 359.1825 (M+H).

Workup

  1. customisolated (57 mg, 75%) as off-white solid

Sources & evidence

ORD record
ord-f6627dca39b34403babfef21e233f0af
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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