1-Cyclopropyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethan-1-amine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid [1-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

Participants

Reaction Steps

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.42 mmol) and α-cyclopropyl-α,5-dimethyl-1,2,4-oxadiazole-3-methanamine (CAN 1155536-64-3, 106.88 mg, 0.64 mmol) as starting materials, and isolated (12 mg, 7.3%) as white solid; LC-MS (UV peak area, ESI) 83.46%, 384.0 (M+H).

Provenance & Evidence