HCID 23393379, compound → HCID 71526222, compound

HRID 1477808Notes

Reaction equation

HRID 1477808 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C@@H:19]([C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1)[C:20]([NH2:22])=[O:21]>>[C:20]([C@@H:19]([NH:18][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=1)(=[O:21])[NH2:22]

Participants

3

Reactant 2

HCID 23393379HCID 23393379, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526222HCID 71526222, compound

Procedure

The title compound was synthesized in analogy to Example 15, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 100 mg, 0.42 mmol) and (S)-2-amino-2-(4-fluoro-phenyl)-acetamide (119.2 mg, 0.64 mmol) as starting materials, and isolated (10 mg, 6.3%) as white solid; LC-MS (UV peak area, ESI) 95.12%, 384.8 (M+H).

Workup

  1. customisolated (10 mg, 6.3%) as white solid

Sources & evidence

ORD record
ord-ceddaca1b6e54b46ad8f353f3fa288fd
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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