HCID 67031617, compound → HCID 71526314, compound

HRID 1477813Notes

Reaction equation

HRID 1477813 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([NH2:34])([CH3:33])[CH2:20][C:21]1[N:22]=[C:23]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:24][C:25]=1[CH3:26]>>[CH3:33][C:19]([NH:34][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([CH3:18])[CH2:20][C:21]1[N:22]=[C:23]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:24][C:25]=1[CH3:26]

Participants

3

Reactant 2

HCID 67031617HCID 67031617, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526314HCID 71526314, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 1,1-dimethyl-2-(5-methyl-2-phenyl-oxazol-4-yl)-ethylamine (57.2 mg, 0.32 mmol) as starting materials and isolated (75 mg, 73.6%) as white solid; LC-MS (UV peak area, ESI) 92.82%, 446.8 (M+H)+.

Workup

  1. customisolated (75 mg, 73.6%) as white solid

Sources & evidence

ORD record
ord-e8c00864011646d1bb547aa47a4105ef
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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