173336-51-1 → HCID 71526407, compound

HRID 1477816Notes

Reaction equation

HRID 1477816 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@H:20]([CH:25]([CH3:27])[CH3:26])[CH2:21][C:22]([NH2:24])=[O:23]>>[C:22]([CH2:21][C@H:20]([NH:19][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH:25]([CH3:27])[CH3:26])(=[O:23])[NH2:24]

Participants

3

Reactant 2

HCID 57478875173336-51-1HCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526407HCID 71526407, compound

Procedure

The title compound was synthesized in analogy to Example 6 using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and (3S)-3-amino-4-methyl-pentanamide monohydrochloride (CAN 173336-51-1, 39 mg, 0.24 mmol) as starting materials and isolated (55 mg, 74%) as light yellow solid; LC-MS (UV peak area, ESI) 98%, 347.2082 (M+H)+.

Workup

  1. customisolated (55 mg, 74%) as light yellow solid

Sources & evidence

ORD record
ord-1ad6b3083c3a4526a0c5bf919f7c7803
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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