HCID 65458295, compound → HCID 71526662, compound

HRID 1477823Notes

Reaction equation

HRID 1477823 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][CH:19]([CH2:23][CH:24]1[CH2:27][CH2:26][CH2:25]1)[C:20]([NH2:22])=[O:21]>>[C:20]([CH:19]([NH:18][C:15]([C:7]1[CH:6]=[N:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH2:23][CH:24]1[CH2:27][CH2:26][CH2:25]1)(=[O:21])[NH2:22]

Participants

3

Reactant 2

HCID 65458295HCID 65458295, compoundHCID 866823315-Cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid

Product 1

HCID 71526662HCID 71526662, compound

Procedure

The title compound was synthesized in analogy to Example 69, using 5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (Example 10 g, 50 mg, 0.21 mmol) and 2-amino-3-cyclobutyl-propionamide (52.5 mg, 0.26 mmol) as starting materials and isolated (30 mg, 39.4%) as white solid; LC-MS (UV peak area, ESI) 99.04%%, 357.4 (M−H)'.

Workup

  1. customisolated (30 mg, 39.4%) as white solid

Sources & evidence

ORD record
ord-ba5cd35d2fce4b55ae791c4b9421ee40
Source dataset
uspto-grants-2016_08
Patent number
US09403808B2

Reaction notes

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