反应详情

A mixture of methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate (3.0 g, 6.8 mmol), as described in Example 18 Step D, in 4 N HCl/MeOH (20 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dissolved in ethyl acetate (80 mL), pH value adjusted to 9-10 with saturated sodium bicarbonate solution, dried over sodium sulfate, then filtered. After removing the organic solvent, the residue was used for the next step without purification. LC/MS m/z=344.1 [M+H]+.

1. customAfter removing the solvent
2. dissolutionthe residue was dissolved in ethyl acetate (80 mL)
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customAfter removing the organic solvent
6. customthe residue was used for the next step without purification