HCID 70562878, compound → HCID 70560138, compound

HRID 1477870Notes

Reaction equation

HRID 1477870 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:15]2[C:23]3[C:18](=[C:19]([NH:24]C(=O)OC(C)(C)C)[CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16]2)([CH2:13][CH3:14])/[CH:9]=[CH:10]/[C:11]#[N:12])=[CH:4][CH:3]=1>Cl.CO>[NH2:24][C:19]1[CH:20]=[CH:21][CH:22]=[C:23]2[C:18]=1[CH:17]=[CH:16][N:15]2[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)([CH2:13][CH3:14])/[CH:9]=[CH:10]/[C:11]#[N:12]

Participants

3

Reactant 1

HCID 70562878HCID 70562878, compound

Product 1

HCID 70560138HCID 70560138, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A mixture of the product from Step A (177 mg, 0.406 mmol) and 4 N HCl/MeOH (10 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dried in vacuo to afford the title compound as a white solid. LC/MS m/z=336.1 [M+H]+.

Workup

  1. customAfter removing the solvent
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-72ebf1c39b78483193c0d4e5c7ab4294
Source dataset
uspto-grants-2016_08
Patent number
US09403807B2

Reaction notes

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