HCID 70583868, compound → HCID 70562272, compound

HRID 1477893Notes

Reaction equation

HRID 1477893 reaction equation
C(OC([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[C:18]([C:26]1[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=1)([CH2:23][CH2:24][F:25])[C:19]([O:21][CH3:22])=[O:20])=O)(C)(C)C>Cl.CO>[NH2:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[C:18]([C:26]1[CH:27]=[CH:28][C:29]([Cl:32])=[CH:30][CH:31]=1)([CH2:23][CH2:24][F:25])[C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 1

HCID 70583868HCID 70583868, compound

Product 1

HCID 70562272HCID 70562272, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

A mixture of the product from Step A (100 mg, 0.217 mmol) and 4 N HCl/MeOH (10 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dried in vacuo to afford the title compound as brown oil. LC/MS m/z=361.1[M+H]+.

Workup

  1. customAfter removing the solvent
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-784c3850ba9143688a31ff7f3afb16d8
Source dataset
uspto-grants-2016_08
Patent number
US09403807B2

Reaction notes

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