Potassium Carbonate → HCID 86705046, compound

Participants

Reaction Steps

To a mixture of tert-butyl (1-(2-(4-chlorophenyl)-1-oxobutan-2-yl)-1H-indol-4-yl)carbamate (412 mg, 1 mmol), as described in Example 21 Step B, and K2CO3 (276 mg, 2 mmol) in methanol (10 mL) was added dimethyl 1-diazo-2-oxopropylphosphonate (230 mg, 1.2 mmol) at room temperature. The mixture was stirred for 2 h and the solid was filtered off and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel chromatography eluting with PE/EA (20/1 to 10/1, v/v) to give the title compound as colorless amorphous solid. LC/MS m/z=352.9[M-tBu+H]+.

Provenance & Evidence