反应详情

To a solution of 4-methyleneoxetan-2-one (60.00 g, 713.69 mmol) in DCM (600 mL) was added phenylmethanamine (91.76 g, 856.43 mmol) dropwise at 0° C. After addition, the reaction mixture was stirred at rt overnight and concentrated in vacuo. The residue was beaten with a mixture of PE and EtOAc (10/1 (v/v), 200 mL) for 1 h and filtered. The filter cake was washed with a mixture of PE and EtOAc (10/1 (v/v), 100 mL) to give the title compound as a yellow solid (136.38 g, 100%).

1. additionAfter addition
2. concentrationconcentrated in vacuo
3. additionThe residue was beaten with a mixture of PE and EtOAc (10/1 (v/v), 200 mL) for 1 h
4. filtrationfiltered
5. washThe filter cake was washed with a mixture of PE and EtOAc (10/1 (v/v), 100 mL)