2-Benzyl-2-azaspiro[4.4]nonan-4-ol → 2-Azaspiro(4.4)nonan-4-ol

HRID 1477945Notes

Reaction equation

C([N:8]1[CH2:12][CH:11]([OH:13])[C:10]2([CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:9]1[C:10]2([CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:11]([OH:13])[CH2:12][NH:8]1

Participants

Conditions

Temperature: 45 °C

Procedure

To a solution of 2-benzyl-2-azaspiro[4.4]nonan-4-ol (20.00 g, 86.5 mmol) in MeOH (200 mL) was added Pd/C (10% wt, 3.00 g). The suspension was stirred at 45° C. under a H2 atmosphere overnight and filtered. The filtered cake was washed with EtOAc (50 mL×3). The filtrate was concentrated in vacuo to give the product as yellow oil (12.21 g, 100%).

Workup

filtrationfiltered
washThe filtered cake was washed with EtOAc (50 mL×3)
concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record: ord-fcb135174e344a1aacc5f57b48615bc0
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09403801B2

Reaction notes

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