HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylic Acid → HCID 118390075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 118410921 | HCID 118410921 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118390075 | HCID 118390075 | 21.1% |
Reaction Steps
To a suspension of N4-methyl-N2-(1-methyl-1H-pyrazol-4-yl)-N4-(2-azaspiro[4.4]nonan-4-yl)pyrimidine-2,4-diamine (0.10 g, 0.31 mmol) in DCM (8.0 mL) was added acrylic acid (55 mg, 0.76 mmol), HATU (0.14 g, 0.37 mmol) and Et3N (62 mg, 0.61 mmol). The mixture was stirred at room temperature for 4 h, then diluted with DCM (50 mL), and washed with water (20 mL) followed by brine (20 mL), dried over anhydrous Na2SO4, then filtered and concentrated in vacuo. The residue was purified by preparative-TLC (DCM/MeOH (v/v)=12/1) to give the product as a light yellow solid (25 mg, 21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403801B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-7f94803799d1449a8c946bea6e0a57b6 |
| Source note | uspto-grants-2016_08 |