Diisopropylethylamine → HCID 118390054, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 8-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-2-azaspiro[4.5]decane-2-carboxylate (3.8 A: 0.14 g, 0.34 mmol) in n-BuOH (2.0 mL) was added 1-methyl-1H-pyrazol-4-amine hydrochloride (89 mg, 0.67 mmol) and DIPEA (0.17 g, 1.35 mmol). The mixture was stirred in a sealed tube and heated to 150° C. for 12 h and then concentrated in vacuo. The residue was purified by silica gel column chromatography (EA/PE (v/v)=4/1) to afford 3.9A as a light yellow solid (0.15 g, 93%).

Provenance & Evidence