Triethylamine → HCID 118390099, compound

Participants

Reaction Steps

To a solution of 2,4-dichloropyrimidine (0.5 g, 3.4 mmol) and tert-butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate (0.89 g, 3.5 mmol) in EtOH (20 mL) was added Et3N (0.5 g, 5 mmol). The mixture was stirred at rt for 24 h, then the reaction mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/2) to give the product as a white solid (0.4 g, 33%).

Provenance & Evidence