Diisopropylethylamine → HCID 118390030, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 8-((2-chloropyrimidin-4-yl)amino)-2-azaspiro[4.5]decane-2-carboxylate (0.4 g, 1.09 mmol) and 1-methyl-1H-pyrazol-4-amine (0.16 g, 1.64 mmol) in n-BuOH (5 mL) was added DIPEA (0.28 g, 2.18 mmol). The mixture was stirred at 150° C. for 16 h then concentrated in vacuo and the residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=10/1) to give the product as a red solid (0.51 g, 98%).

Provenance & Evidence