Hydrochloric Acid → HCID 118410729, compound

Participants

Reaction Steps

To a solution of tert-butyl 8-((2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-2-azaspiro[4.5]decane-2-carboxylate (0.51 g, 1.19 mmol) in DCM (10 mL) was added a solution of HCl in EtOAc (5 mL, 2.83 M) and the mixture was stirred at rt for 16 h. The reaction mixture was diluted with water (10 mL) and adjusted to pH=8 with saturated Na2CO3 solution, then extracted with DCM (20 mL×3), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=10/1) to give the product as a yellow solid (0.17 g, 44%).

Provenance & Evidence