HCID 118390034, compound → 1810076-94-8

Participants

Reaction Steps

To a solution of tert-butyl 4-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate (10.87 g, 45.04 mmol) in DCM (200 mL) were added 4 Å molecular sieve (20.00 g) followed by PCC (24.27 g, 112.6 mmol) slowly and the mixture was stirred at rt overnight. The resulting mixture was filtered and the filter cake was washed with EtOAc (50 mL×3). The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/50 to 1/10) to give the product as a white solid (8.56 g, 79.4%).

Provenance & Evidence