反应详情

温度

120 °C

To a suspension of 2,2′-(1-(tert-butoxycarbonyl)pyrrolidine-3,4-diyl)diacetic acid (3.40 g, 11.8 mmol) in Ac2O (21 mL) was added NaOAc (0.78 g, 9.5 mmol) and the reaction mixture was stirred at 120° C. for 3 h. After that, the resulting mixture was cooled down to rt then filtered and washed with EtOAc (20 mL×2). The filtrate was concentrated in vacuo and the residue was purified by silica gel chromatography (EtOAc/PE (v/v)=1/4) to give the title compound as orange yellow oil (1.38 g, 55.0%).

1. temperatureAfter that, the resulting mixture was cooled down to rt
2. filtrationthen filtered
3. washwashed with EtOAc (20 mL×2)
4. concentrationThe filtrate was concentrated in vacuo
5. customthe residue was purified by silica gel chromatography (EtOAc/PE (v/v)=1/4)