HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylic Acid → HCID 118389999, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylic Acid | HCID 6581 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 118410921 | HCID 118410921 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118389999 | HCID 118389999 | 23.5% |
Reaction Steps
To a suspension of N4-methyl-N2-(1-methyl-1H-pyrazol-4-yl)-N4-(2-azaspiro[4.4]nonan-4-yl)pyrimidine-2,4-diamine (0.10 g, 0.29 mmol) in DCM (10.0 mL) were added acrylic acid (21 mg, 0.29 mmol), HATU (0.13 g, 0.35 mmol) and Et3N (59 mg, 0.59 mmol). The mixture was stirred at rt for 1.5 h, and then diluted with DCM (30 mL), washed with brine (20 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by preparative-TLC (DCM/MeOH (v/v)=20/1) to give the title compound as a light yellow solid (27 mg, 21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403801B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-1b31e77857714f1ba41518319b20c2bb |
| Source note | uspto-grants-2016_08 |