Triethylamine → HCID 118390066, compound

Participants

Reaction Steps

To a solution of 2,4,5-trichloropyrimidine (500 mg, 2.73 mmol) and tert-butyl 4-amino-2-azaspiro[4.4]nonane-2-carboxylate (687.37 mg, 2.86 mmol) in EtOH (20 mL) was added Et3N (552.50 mg, 5.46 mmol) and the reaction mixture was stirred at rt overnight. The resulting mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v)=10/1 to 5/1) to give the product as a white solid (930 mg, 88.2%).

Provenance & Evidence