Diisopropylethylamine → HCID 118390058, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-((2,5-dichloropyrimidin-4-yl)amino)-2-azaspiro[4.4]nonane-2-carboxylate (830 mg, 2.15 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloride (344.74 mg, 2.58 mmol) in n-BuOH (8 mL) was added DIPEA (833.60 mg, 6.45 mmol) and the reaction mixture was stirred at 150° C. overnight. The resulting mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=100/1) to give the product as a white solid (800 mg, 83%).

Provenance & Evidence