反应详情

温度

0 °C

A mixture of 4'-chloro-2'-fluoroacetanilide (51 g, 0.272 mol) in concentrated sulfuric acid (100 mL) is cooled to 0° C., treated with nitric acid (90% real, 14 mL, 0.300 mol) over 45 minutes, stirred for 10 minutes, and poured onto ice. The resultant aqueous mixture is filtered to obtain a tan solid which is washed with water, dried overnight, and recrystallized from a chloroform/hexanes (17:1) solution to give the title product as a yellow solid.

1. additionpoured onto ice
2. filtrationThe resultant aqueous mixture is filtered
3. customto obtain a tan solid which
4. washis washed with water
5. customdried overnight
6. customrecrystallized from a chloroform/hexanes (17:1) solution