Triethylamine → HCID 118390097, compound

Participants

Reaction Steps

To a solution of 2,4,5-trichloropyrimidine (355.7 g, 1.94 mmol) and tert-butyl 2-(methylamino)-7-azaspiro[4.5]decane-7-carboxylate (403.2 g, 1.50 mmol) in EtOH (10 mL) was added Et3N (315.5 mg, 3.12 mmol). After addition, the reaction mixture was stirred at rt overnight and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/8) to give the title compound as yellow oil (470 mg, 75.4%).

Provenance & Evidence