Triethylamine → HCID 118390023, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,4-dichloro-5-methylpyrimidine (300 mg, 1.84 mmol) and tert-butyl 9-(methylamino)-3-azaspiro[5.5]undecane-3-carboxylate (573.32 mg, 2.03 mmol) in ethanol (30 mL) was added N,N-diethylethanamine (372.38 mg, 3.68 mmol). The reaction mixture was stirred at 100° C. overnight and then concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/5) to give the title compound as yellow oil (165 mg, 22%).

Provenance & Evidence