Diisopropylethylamine → HCID 118390052, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 9-((2-chloro-5-methylpyrimidin-4-yl)(methyl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (211 mg, 0.52 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloride (160.3 mg, 1.20 mmol) in butan-1-ol (5 mL) was added DIPEA (201.63 mg, 1.56 mmol). The reaction mixture was stirred at 150° C. in a sealed tube overnight, then cooled down to rt, and concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=100/1 to 10/1) to give the title compound as a white solid (176.87 mg, 73%).

Provenance & Evidence