Hydrochloric Acid → HCID 131736500, compound

Participants

Reaction Steps

To a suspension of tert-butyl 9-(methyl(5-methyl-2-((1-methyl-1H-pyrazol-4-yl) amino)pyrimidin-4-yl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (250 mg, 0.53 mmol) in dichloromethane (15 mL) was added the solution of HCl in EtOAc (3 mL, 12 mmol). The reaction mixture was stirred at rt for 2 h. The mixture was adjust to pH=8-9 with the saturated solution of NaHCO3, then the mixture was diluted with 20 mL H2O and exacted with DCM/MeOH (10/1, 10 mL×3). The combined organic layers were washed with brine (20 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash silica gel column chromatography (DCM/MeOH (v/v)=10/1 to 5/1) to give the title compound as a yellow solid (135 mg, 68.6%).

Provenance & Evidence