Triethylamine → HCID 118390056, compound

Participants

Reaction Steps

To a solution of 2,4,5-trichloropyrimidine (300 mg, 1.64 mmol) and tert-butyl 9-(methylamino)-3-azaspiro[5.5]undecane-3-carboxylate (511.18 mg, 1.81 mmol) in ethanol (15 mL) was added N,N-diethylethanamine (331.90 mg, 3.28 mmol). The reaction mixture was stirred at rt overnight and then concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/10 to 1/5) to give the title compound as yellow oil (101.83 mg, 14.5%).

Provenance & Evidence