Diisopropylethylamine → HCID 118390068, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 9-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (241 mg, 0.56 mmol) and 1-methyl-1H-pyrazol-4-amine hydrochloride (172.32 mg, 1.29 mmol) in butan-1-ol (5 mL) was added DIPEA (217.14 mg, 1.68 mmol). The reaction mixture was stirred at 150° C. in a sealed tube overnight, then cooled down to rt, and concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=100/1 to 10/1) to give the title compound as a white solid (198 mg, 72%).

Provenance & Evidence