反应详情

To a solution of 1-(cyclopropylmethyl)-4-nitro-1H-pyrazole (8.37 g, 50.1 mmol) in methanol (150 mL) was added 10% Pd/C (840.0 mg, 0.7893 mmol). The suspension was stirred at room temperature under a H2 atmosphere for 2 h. Filtered and the filter cake was washed with MeOH (50 mL×3). The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/100 to 1/50) to give the title compound as purple oil (5.5 g, 80%).

1. filtrationFiltered
2. washthe filter cake was washed with MeOH (50 mL×3)
3. concentrationThe filtrate was concentrated in vacuo
4. customthe residue was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/100 to 1/50)