Methylhydrazine → 3-cyclopropyl-1-methyl-1H-pyrazol-5-amine

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-cyclopropyl-3-oxo-propanenitrile (2.22 g, 20.3 mmol) in HOAc (40 mL) was added methylhydrazine (40% [w/w] in water, 2.81 g, 24.4 mmol). The reaction mixture was stirred at 100° C. overnight and then concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM) to give the title compound as yellow oil (2.80 g, 100%).

Provenance & Evidence