Triethylamine → HCID 118390079, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-methyl-N2-(1-methyl-1H-pyrazol-4-yl)-N4-(octahydrocyclopenta[c]pyrrol-5-yl)pyrimidine-2,4-diamine (112.0 mg, 0.36 mmol) and 6-chloropyridine-3-carbonitrile (102.5 mg, 0.74 mmol) in a mixture of DCM (5 mL) and MeOH (5 mL) was added Et3N (200.7 mg, 1.98 mmol). The reaction mixture was stirred at 45° C. overnight and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/40) to give the title compound as a beige solid (0.12 g, 81%).

Provenance & Evidence