Triethylamine → HCID 118390015, compound

Participants

Reaction Steps

To a suspension of 5-methyl-N2-(1-methyl-1H-pyrazol-4-yl)-N4-(octahydrocyclopenta[c]pyrrol-5-yl)pyrimidine-2,4-diamine (122.4 mg, 0.39 mmol) and N,N-diethylethanamine (103.9 mg, 1.03 mmol) in DCM (10 mL) was added methanesulfonyl chloride (98.4 mg, 0.86 mmol). The reaction mixture was stirred at rt for 2 h, quenched with H2O (30 mL) and extracted with DCM (100 mL×3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/20) to give the title compound as a beige solid (64.8 mg, 42.4%).

Provenance & Evidence