Trifluoroacetic acid → HCID 118390074, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 5-((2,5-dichloropyrimidin-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (579.1 mg, 1.55 mmol) and 1,5-dimethylpyrazol-4-amine hydrochloride (446.8 mg, 3.03 mmol) in dioxane (10 mL) was added trifluoroacetic acid (862.8 mg, 7.57 mmol). The reaction mixture was stirred at 100° C. overnight and adjusted to pH=10 with a saturated Na2CO3 solution, then extracted with DCM (100 mL×3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM=1/10) to give the title compound as a beige solid (105.6 mg, 19.6%).

Provenance & Evidence