Triethylamine → HCID 118389995, compound

Participants

Reaction Steps

To a suspension of 2-((1-methyl-1H-pyrazol-3-yl)amino)-4-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyrimidine-5-carbonitrile (165.2 mg, 0.5092 mmol) and 2-cyanoacetic acid (65 mg, 0.7642 mmol) in dichloromethane (20 mL) and N,N-dimethylformamide (5 mL) were added HATU (387.5 mg, 1.019 mmol) and N,N-diethylethanamine (103.5 mg, 1.023 mmol). The mixture was then stirred at rt for 1 h and then quenched with H2O (20 mL), and the resulted mixture was extracted with DCM/MeOH (10/1, 20 mL×3). The combined organic phases were washed with brine (50 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=10/1) to give the title compound as a white solid (36 mg, 18.06%).

Provenance & Evidence