Diisopropylethylamine → HCID 118390039, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of tert-butyl 5-((2,5-dichloropyrimidin-4-yl)(methyl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (249.1 mg, 0.64 mmol) and 1-methylpyrazol-4-amine hydrochloride (333.1 mg, 2.49 mmol) in n-BuOH (10 mL) was added DIPEA (452.0 mg, 3.46 mmol). The reaction mixture was stirred at 150° C. in a sealed tube for 28 h and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=2/1) to give the title compound as brown oil (230.8 mg, 80.1%).

Provenance & Evidence